Morphological Evaluation Of Opossum Lower Esophageal Sphincter
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چکیده
منابع مشابه
Biphasic relaxation of the opossum lower esophageal sphincter: roles of NO ⋅, VIP, and CGRP.
Vasoactive intestinal polypeptide (VIP) and nitric oxide (NO ⋅) are thought to mediate lower esophageal sphincter (LES) relaxation. Transverse muscle strips from the opossum LES were used to test this hypothesis. Electrical field stimulation (EFS) produced a biphasic LES relaxation: a rapid component during the stimulus was more prominent at lower stimulus frequencies, and a sustained component...
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Lipopolysaccharide (LPS), given in vivo, modulates opossum esophageal motor functions by inducing the inducible nitric oxide synthase (iNOS), which increases nitric oxide (NO) production. Superoxide, a NO scavenger, is generated during this endotoxemia. Superoxide is cleared by superoxide dismutase (SOD) and catalase (CAT) to protect the physiological function of NO. This study examined whether...
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The ionic basis underlying the maintenance of myogenic tone of lower esophageal sphincter circular muscle (LES) was investigated in opossum with the use of standard isometric tension and conventional intracellular microelectrode recordings in vitro. In tension recording studies, nifedipine (1 microM) reduced basal tone to 27.7 +/- 3.8% of control. The K(+) channel blockers tetraethylammonium (T...
متن کاملBiphasic relaxation of the opossum lower esophageal sphincter: roles of NO z, VIP, and CGRP
Uc, Aliye, S. T. Oh, Joseph A. Murray, Eugene Clark, and Jeffrey L. Conklin. Biphasic relaxation of the opossum lower esophageal sphincter: roles of NO z, VIP, and CGRP. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G548–G554, 1999.—Vasoactive intestinal polypeptide (VIP) and nitric oxide (NO z) are thought to mediate lower esophageal sphincter (LES) relaxation. Transverse muscle strip...
متن کاملMechanics of sphincter action. Studies on the lower esophageal sphincter.
The purpose of this study was to evaluate the mechanical factors involved in the genesis of lower esophageal sphincter pressure. We determined the relationship between intraluminal pressure and inside diameter, estimated the ratio between the wall thickness to inside radius, and calculated the tension in the wall of the lower esophageal sphincter as a function of the inside diameter. Various de...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1978
ISSN: 0016-5085
DOI: 10.1016/0016-5085(78)93763-0